oop diuretic that acts by inhibiting effects on electrolyte reabsorption in the ascending loop of Henlé and distal renal tubule. It increases the water excretion by increasing the Na, Cl, and K ions excretion.Indications: Edema. Resistant hypertension. Chronic heart failure [water retention]. Acute pulmonary edema.Points of interest: This medication may cause dizziness, get up from a lying or sitting position gradually to avoid dizziness on standing. Monitoring of serum sodium, potassium, and creatinine is recommended.